PNC Park in Pittsburgh, PA will play host to a Friday night clash between the Arizona Diamondbacks and the Pittsburgh Pirates. Tonight’s game will be the start a 3-game weekend series in Pittsburgh. According to sportsbook odds, the Pirates are coming in this series as an underdog with a 42-61 record. Can the Pirates overcome the odds and beat the Pirates? Here is what our experts have to say in this Diamondbacks vs Pirates MLB Betting Pick and prediction.
For Diamondbacks fans, this could be a baseball betting opportunity to make some money. This is because the Arizona Diamondbacks are sitting at 50-53 on the season after a frustrating sweep by the Houston Astros. They lost all three games in that series, with scores of 6-3, 3-1, and 4-3. The last game especially stung.
On the other hand, Arizona jumped out to an early 1-0 lead and even managed to tie things up in the eighth inning, but then gave up the game-winning run in the ninth.
Diamondbacks vs Pirates MLB Game Info
- Date and Time: 07/25/2025 at 6:40 PM ET
- Location: PNC Park
- Watch on: MLB Extra Innings, Fubo, or SportsNet Pittsburgh for regional viewers
Diamondbacks vs Pirates MLB Betting Odds
| Team | Pointspread | Total | MoneyLine |
| Arizona Diamondbacks | -1.5 (+130) | O9 (-104) | -126 |
| Pittsburgh Pirates | +1.5 (-196) | U9 (-118) | +108 |
*MLB Betting Odds courtesy of BetOnline.ag
Diamondbacks vs Pirates Prediction and Analysis for 07/25/2025
Arizona Diamondbacks Betting Breakdown:
The Diamondbacks are currently 50-53 and looking ahead to upcoming series against the Tigers, Athletics, and Padres. These are three matchups that could give them a chance to gain some momentum. Offensively, Arizona has been steady. They’re hitting .253 as a team, with a .329 on-base percentage and a .446 slugging percentage.
On the pitching side, the D-backs have had some ups and downs, carrying a team ERA of 4.58 and a 1.33 WHIP. Geraldo Perdomo has been one of the most consistent bats in the lineup, leading the team with 106 hits and 72 RBIs. Meanwhile, Eugenio Suárez and Lourdes Gurriel Jr. have also been key contributors, combining for 184 hits and 134 RBIs so far.
Diamondbacks Pitching Preview:
Taking the mound tonight is Ryne Nelson. He’s been solid this season with a 6-2 record, a 3.52 ERA, and 69 strikeouts. He’s also had success against the Pirates in the past, posting a 1-0 record with a 3.09 ERA and 11 strikeouts in his career against them.
Pittsburgh Pirates Betting Breakdown:
The Pittsburgh Pirates come into this game with a 42-61 record, but they’re feeling good after sweeping the Tigers in their last series. They won all three games by scores of 3-0, 8-5, and 6-1. In the series finale, Pittsburgh jumped out early with six runs in the first three innings and never looked back.
They finished the game with eight hits, and Spencer Horwitz was the standout. He went 1-for-4 but made it count with a home run and four RBIs. On the mound, Bailey Falter delivered a strong performance, giving up just one run over seven innings. Carmen Mlodzinski came in to close out the final two.
Before the Tigers series, things weren’t going quite as well. The Pirates had been swept by the White Sox and dropped two out of three to the Twins. They’ve split their last six games overall and are currently at the bottom of the NL Central standings.
This season, Pittsburgh’s pitching has actually been a bright spot. Their team ERA is 3.84, with a 1.21 WHIP and a .236 opponent batting average making for pretty solid numbers. On offense, though, they’ve struggled. The team has scored 350 runs so far with a .232 batting average and a .301 on-base percentage.
Oneil Cruz leads the Pirates with 16 home runs and 40 RBIs, while Bryan Reynolds has chipped in with 10 homers and 50 RBIs of his own.
Pirates Pitching Preview:
On the mound tonight for Pittsburgh is Mike Burrows. He’s 1-3 on the season with a 4.70 ERA and a 1.41 WHIP over 46 innings pitched.
Diamondbacks vs Pirates MLB Betting Pick
Pittsburgh enters this series riding high after a strong sweep of the Tigers, while Arizona is looking to bounce back after getting swept by the Astros. The Pirates have
been solid at home with a 29-24 record, while the Diamondbacks are just under .500 on the road at 24-25.
Arizona has been one of the better scoring teams in the league, but their bats went quiet in Houston, putting up just seven runs across three games. They’ll look to turn things around with Ryne Nelson on the mound as he’s been reliable lately, giving up two earned runs or fewer in four of his last five starts.
Pittsburgh will counter with Mike Burrows, who’s also been solid, allowing two or fewer earned runs in three of his last four outings. That said, the Pirates’ sweep of Detroit seemed more about the Tigers struggling than Pittsburgh dominating. I expect the D-backs to rebound here.
Bet on the Arizona Diamondbacks at -126
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